Research Scientist - Investigative Toxicology

Company: Takeda Pharmaceutical
Location: Lynn
Posted on: May 9, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Research Scientist - Investigative Toxicology, in our Cambridge, Massachusetts office.At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Here, you will be a vital contributor to our inspiring, bold mission.As a Research Scientist - Investigative Toxicology, working on the Global Investigative Toxicology team, you will be empowered to work as part of a global team of safety assessment scientists to detect and de-risk toxicities associated with cell and gene therapies. The Global Investigative Toxicology team is a cross-functional team of scientists that aim to detect and de-risk toxicity in Takeda's portfolio to help make safer and more effective medicines. We are looking for a Research Scientist to support these efforts across cell and gene therapy platforms. The Research Scientist will contribute ideas and deliver decision-making data to inform design and prioritization of cell and gene therapy candidates. - A typical day will include:POSITION OBJECTIVES:

• Design and implement early safety assessment screening strategies to enable the progression of optimized therapeutic candidates
• Conduct cell-based in vitro assays to characterize immune-mediated toxicities for medicines in discovery & development
• Develop novel in vitro model systems to assess safety risks associated with new cell and gene therapy designsPOSITION ACCOUNTABILITIES:
  • Develop, design, execute, and interpret in vitro cell-based assays to characterize diverse mechanisms of cell and gene therapies
  • Maintain cultures of immortalized tumor cell lines, primary cell types of various origin (lung, liver, kidney, intestine, pancreas, etc.), and primary immune cells (T cells, B cells, NK cells, etc.)
  • Perform fit-for-purpose ex vivo analyses to assess phenotypic and functional correlates of toxicity
  • Prepare experimental protocols, analyze experimental data, and present study results in team and department meetings
  • Contribute ideas to drive innovation within investigative toxicology and with key collaborators (e.g. pharmacology, DMPK, bioinformatics)
  • Document experimental methods and findings in electronic laboratory notebookEDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:
    • PhD degree in a scientific discipline (or equivalent), or MS with 6+ years relevant experience, or BS with 8+ years relevant experience
    • Expert with standard aseptic cell culture technique, including experience culturing various tumor cell lines and primary cells. -
    • Broad experience with cell-based functional assays, including cytotoxicity, cytokine release, and proliferation assays. Experience with flow cytometry is a plus.
    • Basic experience with molecular biology techniques including RNA/DNA extraction, qPCR, western blot
    • Experience working in a matrixed team environment at a pharmaceutical company and/or CRO
    • Broad scientific knowledge in immunology and pharmacology
    • Self-motivated with strong time management and organizational skills
    • Ability to balance multiple projects and flexible with changing priorities
    • Highly collaborative with demonstrated ability to work in a matrixed team environment
    • Excellent oral and written communication skillsAbsent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.This job posting excludes CO applicantsWHAT TAKEDA CAN OFFER YOU:
      • 401(k) with company match and Annual Retirement Contribution Plan
      • Tuition reimbursement
      • Company match of charitable contributions
      • Health & Wellness programs including onsite flu shots and health screenings
      • Generous time off for vacation and the option to purchase additional vacation days
      • Community Outreach ProgramsEmpowering Our People to ShineLearn more at takedajobs.comTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.#LI-NS1EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Lynn , Research Scientist - Investigative Toxicology, Other , Lynn, Massachusetts