Research Scientist - Investigative Toxicology
Company: Takeda Pharmaceutical
Location: Lynn
Posted on: May 9, 2022
Job Description:
By clicking the "Apply" button, I understand that my employment
application process with Takeda will commence and that the
information I provide in my application will be processed in line
with Takeda's and . I further attest that all information I submit
in my employment application is true to the best of my
knowledge.Job DescriptionAre you looking for a patient-focused,
innovation-driven company that will inspire you and empower you to
shine? Join us as a Research Scientist - Investigative Toxicology,
in our Cambridge, Massachusetts office.At Takeda, we are
transforming the pharmaceutical industry through our R&D-driven
market leadership and being a values-led company. To do this, we
empower our people to realize their potential through life-changing
work. Certified as a Global Top Employer, we offer stimulating
careers, encourage innovation, and strive for excellence in
everything we do. We foster an inclusive, collaborative workplace,
in which our global teams are united by an unwavering commitment to
deliver Better Health and a Brighter Future to people around the
world.Here, you will be a vital contributor to our inspiring, bold
mission.As a Research Scientist - Investigative Toxicology, working
on the Global Investigative Toxicology team, you will be empowered
to work as part of a global team of safety assessment scientists to
detect and de-risk toxicities associated with cell and gene
therapies. The Global Investigative Toxicology team is a
cross-functional team of scientists that aim to detect and de-risk
toxicity in Takeda's portfolio to help make safer and more
effective medicines. We are looking for a Research Scientist to
support these efforts across cell and gene therapy platforms. The
Research Scientist will contribute ideas and deliver
decision-making data to inform design and prioritization of cell
and gene therapy candidates. - A typical day will include:POSITION
OBJECTIVES:
- Design and implement early safety assessment screening
strategies to enable the progression of optimized therapeutic
candidates
- Conduct cell-based in vitro assays to characterize
immune-mediated toxicities for medicines in discovery &
development
- Develop novel in vitro model systems to assess safety risks
associated with new cell and gene therapy designsPOSITION
ACCOUNTABILITIES:
- Develop, design, execute, and interpret in vitro cell-based
assays to characterize diverse mechanisms of cell and gene
therapies
- Maintain cultures of immortalized tumor cell lines, primary
cell types of various origin (lung, liver, kidney, intestine,
pancreas, etc.), and primary immune cells (T cells, B cells, NK
cells, etc.)
- Perform fit-for-purpose ex vivo analyses to assess phenotypic
and functional correlates of toxicity
- Prepare experimental protocols, analyze experimental data, and
present study results in team and department meetings
- Contribute ideas to drive innovation within investigative
toxicology and with key collaborators (e.g. pharmacology, DMPK,
bioinformatics)
- Document experimental methods and findings in electronic
laboratory notebookEDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:
- PhD degree in a scientific discipline (or equivalent), or MS
with 6+ years relevant experience, or BS with 8+ years relevant
experience
- Expert with standard aseptic cell culture technique, including
experience culturing various tumor cell lines and primary cells.
-
- Broad experience with cell-based functional assays, including
cytotoxicity, cytokine release, and proliferation assays.
Experience with flow cytometry is a plus.
- Basic experience with molecular biology techniques including
RNA/DNA extraction, qPCR, western blot
- Experience working in a matrixed team environment at a
pharmaceutical company and/or CRO
- Broad scientific knowledge in immunology and pharmacology
- Self-motivated with strong time management and organizational
skills
- Ability to balance multiple projects and flexible with changing
priorities
- Highly collaborative with demonstrated ability to work in a
matrixed team environment
- Excellent oral and written communication skillsAbsent an
approved religious or medical reason, all US office-based and
lab-based Takeda employees who work fully on-site or in a hybrid
model (as determined by Takeda) must be fully vaccinated to work at
a Takeda site or to engage with Takeda colleagues or anyone else on
behalf of Takeda. US field-based employees must be fully vaccinated
as a condition of employment, absent an approved religious or
medical reason. US employees who work at a Takeda manufacturing
facility, and those who work at a BioLife center or BioLife lab,
may be subject to different guidelines. If you are contacted by a
Takeda recruiter about your job application, we encourage you to
seek more information on the applicable guidelines for the Business
Unit/Function to which you have applied.This job posting excludes
CO applicantsWHAT TAKEDA CAN OFFER YOU:
- 401(k) with company match and Annual Retirement Contribution
Plan
- Tuition reimbursement
- Company match of charitable contributions
- Health & Wellness programs including onsite flu shots and
health screenings
- Generous time off for vacation and the option to purchase
additional vacation days
- Community Outreach ProgramsEmpowering Our People to ShineLearn
more at takedajobs.comTakeda is proud in its commitment to creating
a diverse workforce and providing equal employment opportunities to
all employees and applicants for employment without regard to race,
color, religion, sex, sexual orientation, gender identity, gender
expression, parental status, national origin, age, disability,
citizenship status, genetic information or characteristics, marital
status, status as a Vietnam era veteran, special disabled veteran,
or other protected veteran in accordance with applicable federal,
state and local laws, and any other characteristic protected by
law.#LI-NS1EEO StatementTakeda is proud in its commitment to
creating a diverse workforce and providing equal employment
opportunities to all employees and applicants for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, gender expression, parental status, national
origin, age, disability, citizenship status, genetic information or
characteristics, marital status, status as a Vietnam era veteran,
special disabled veteran, or other protected veteran in accordance
with applicable federal, state and local laws, and any other
characteristic protected by law.LocationsBoston, MAWorker
TypeEmployeeWorker Sub-TypeRegularTime TypeFull time
Keywords: Takeda Pharmaceutical, Lynn , Research Scientist - Investigative Toxicology, Other , Lynn, Massachusetts
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