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Research Associate/Sr Research Associate- Biotransformation

Company: Takeda Pharmaceutical
Location: Lynn
Posted on: May 12, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionOBJECTIVES:Research Associate/Sr Research Associate: -Metabolite ID/Catabolite ID/Biotransformation, DMPK, Takeda Pharmaceutical Company, Cambridge, MAThe DMPK department at Takeda, Cambridge, MA is seeking a highly motivated Research Associate or Sr Research Associate to join the Drug Metabolism group. The primary responsibilities will be profiling and characterization of metabolites (small molecules, ASO, and siRNA )/catabolites (ADCs, proteins, and peptides) from complex biological matrices. A strong background in delineating biotransformation pathways and structural elucidation by LC-MS is required. A successful candidate must exhibit strong communication and interpersonal skills and desire to work in a fast-paced, flexible and dynamic environment. Experience with in vivo preclinical and clinical ADME studies and understanding of clearance route, mechanism and the role of metabolism/catabolism is essential. - The position level will depend on the level of experience in the relevant areas.ACCOUNTABILITIES: 1. - - - - Identification and structural elucidation of metabolites/catabolites of small molecule, ASO, siRNA, ADC, peptide, and protein drug candidates using LC-MS and other structure elucidation tools.2. - - - - Hands on experience in operation, maintenance & trouble shooting of LC-MS, -immune-capturing technology, and other instruments.3. - - - - Conduct in vitro drug metabolism studies of small molecules, payload release assays of ADCs, catabolism and stability assessment of peptide and protein drugs.4. - - - - Conduct non-radio-labeled and radio-labeled metabolite profiling experiments from in vitro and in vivo studies (pre-clinical and clinical mass balance studies).5. - - - - Work independently or under guidance and report data in written reports and team presentations as required.6. - - - - Maintain accurate records of the study data.EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS: - - - - - - - Applicants should possess a MS or BS in Organic/Analytical/Medicinal/Bio chemistry or relevant discipline -with 0 year (MS) or 2+ years (BS) of pharmaceutical industry experience. - - - - - - - Hands-on experience with HPLC and LC-MS are preferred. Familiarity with Sciex Q-TOF and/or Thermo Hybrid Orbitrap high resolution mass spectrometry instruments and metabolite identification is preferred. - - - - - - - Good understanding of organic chemistry, structure elucidation and xenobiotic metabolism - - - - - - - Experience in utilizing radiolabeled material in drug metabolism studies is a plus. - - - - - - - Experience in immunocapture and protein/peptide qualitative analysis by LC-MS is a plus. - - - - - - - Experience in metabolism of new modalities (e.g. ASO, siRNA) is a plus. - - - - - - - Experience in metabolite/catabolite identification in in vitro systems (hepatocytes, microsome, etc.) and in vivo matrices (urine, feces, bile and plasma). - - - - - - - The candidate must be able to analyze data and note significant deviations and maintain detailed, accurate and comprehensible study documentation. - - - - - - - The individual is also expected to be highly organized, a team player, enthusiastic about drug discovery, and possess strong communication skills.Employees are eligible to participate in Medical, Dental. Vision, Life Insurance, 401(k), Charitable Contribution Match, Company Holidays, Personal & Vacation Days, Student Loan Repayment Program and Paid Volunteer Time Off.Effective November 1, 2021, absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. Candidates are encouraged to speak with their recruiter to seek further information on the applicable guidelines for the Business Unit/Function for which they have applied.

  • In accordance with the CO Equal Pay Act, -Colorado Applicants Are Not Permitted to Apply.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Lynn , Research Associate/Sr Research Associate- Biotransformation, Other , Lynn, Massachusetts

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