? 3 Days Left! Associate Director Crystallization
Company: Sanofi
Location: Cambridge
Posted on: July 2, 2025
|
|
|
Job Description:
Job Description About the Job We are an innovative global
healthcare company with one purpose: to chase the miracles of
science to improve people’s lives. We’re also a company where you
can flourish and grow your career, with countless opportunities to
explore, make connections with people, and stretch the limits of
what you thought was possible. Ready to get started? Position
Overview/Department Description: We are looking for a highly
motivated individual with a mindset to lead the implementation of
changes. She/He will be recognized as technical expert in the field
of crystallization and solid-state chemistry and will have
leadership experience. The successful candidate will work in a
cutting-edge scientific global crystallization department in
Sanofi’s R&D CMC Synthetic organization. The job is in
Cambridge MA, but close collaboration with colleagues in France is
required. Crystallization Scientists work cross functionally to
select active pharmaceutical ingredients (API) solid forms for
development and deliver robust commercial API crystallization
processes. Process development may be directed to either batch or
continuous processes. Collaborative work with Chemists and
Engineers on complex drug substance intermediate crystallizations
will also be required. Work starts at candidate selection and
continues to commercial launch. We strongly believe that innovation
in process development, data science and modelling will be key
drivers to transform Pharma process development. Key
Responsibilities: - Lead a team that works with internal partners
in Drug Product development, Biopharmaceutics and Analytical to
select the API physical form for new NCEs. This includes assessment
of the manufacturability (API solid form space complexity, physical
properties, scalability, stability) - Develop and mentor others to
develop processes to consistently produce API with the required
quality attributes using both batch and continuous platforms.
Expectations include; - Team Interactions – Facilitate close
interactions with project team members such as Chemists, Analysts,
Formulators and Engineers/Modelers to develop API processes that
are closely coordinated with API route selection and Drug Product
development. - Digital Development – Lead the transformation of
development from traditional data driven statistical approaches to
more efficient and effective Digital Development. - Domain
knowledge - Use a strong background in Crystallization Engineering
and/or Solid-State Chemistry to understand and apply strategies to
control API physiochemical properties such as particle size
distribution, impurities concentration and crystal form. -
Experimentation – Apply strong lab skills to deliver well designed
efficient experimental plans required for process development
across a wide range of crystallization, isolation and size
reduction process equipment. - Analytical – Perform physiochemical
analysis to understand process and characterize products this
includes but is not limited to XRD, DSC, PSD, SEM, optical
microscopy, LC, GC, KF. - The candidate will be expected to
dedicate part of their time to work on continuous improvement with
internal resource or through academic collaboration. Some potential
areas for improvement include; - Development of models to
understand and describe the rejection of impurities in intermediate
and API crystallizations. - Develop crystallization models (Digital
Twins) for batch and continuous process and use Global System
Analysis tools (e.g. gPROMS) to identify CPPs, Design Space and
Control Strategies. - Identify and test Particle Engineering
approaches to improve API physical properties such as
supersaturation control, seed conditioning and agglomeration. -
Author publications, patents and present in technical conferences.
- Lead Tech Transfer of crystallization to the Pilot Plant and
Manufacturing. This includes support for technical and HSE risk
assessments, review of Master Batch Records and campaign coverage
for key batches. - Provide concise technical presentations to
communicate work to project teams, cross functional teams and
management. Document all work on projects and continuous
improvements in eLNB experiments and summarize in Technical
Reports. - Establish/extend external network by providing
leadership on academic, industrial, or government sponsored
collaborations. Steer collaboration projects to address gaps in
scientific knowledge. About you Basic Qualifications: - PhD in
Chemical engineering or Solid State Chemistry or any related field
with a minimum of 6 years of experience or Masters’ degree with a
minimum of 10 years of experience in academia or industry. - Proven
track record developing and leading other to develop
crystallization processes. - An ability to work as part of a team,
engaging other scientists with complementary skill sets in the
field of pharmaceutical development. - A change agent mentality,
proposing novel approach to challenging scientific questions and
exploring new modeling approaches. - Ability to design and deliver
lab experimental plans for crystallization process development
including use of typical process and analytical experiment. -
Familiar with PAT and common off-line analytical technics such as
HPLC, GC and NMR Preferred Qualifications: - Modeling experience
using gPROMS, DynoChem, Matlab, Python or similar programming
languages. - Some knowledge in Multivariate Analysis, chemometrics
and statistics - Experience in the development and scale-up of
continuous processes Why Choose Us? - Bring the miracles of science
to life alongside a supportive, future-focused team. - Discover
endless opportunities to grow your talent and drive your career,
whether it’s through a promotion or lateral move, at home or
internationally. - Enjoy a thoughtful, well-crafted rewards package
that recognizes your contribution and amplifies your impact. - Take
good care of yourself and your family, with a wide range of health
and wellbeing benefits including high-quality healthcare,
prevention and wellness programs and at least 14 weeks’
gender-neutral parental leave. Sanofi Inc. and its U.S. affiliates
are Equal Opportunity and Affirmative Action employers committed to
a culturally diverse workforce. All qualified applicants will
receive consideration for employment without regard to race; color;
creed; religion; national origin; age; ancestry; nationality;
marital, domestic partnership or civil union status; sex, gender,
gender identity or expression; affectional or sexual orientation;
disability; veteran or military status or liability for military
status; domestic violence victim status; atypical cellular or blood
trait; genetic information (including the refusal to submit to
genetic testing) or any other characteristic protected by law.
GD-SA LI-SA? LI-Onsite VHD All compensation will be determined
commensurate with demonstrated experience. Employees may be
eligible to participate in Company employee benefit programs, and
additional benefits information can be found here.
Keywords: Sanofi, Lynn , ? 3 Days Left! Associate Director Crystallization, Science, Research & Development , Cambridge, Massachusetts
