QSP Modeler

Company: Eli Lilly and Company
Location: Boston
Posted on: March 25, 2026

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Eli Lilly and Company stands at the forefront of groundbreaking research, with a portfolio spanning small molecules, peptides, antibodies, genetic medicines, RNA therapeutics, and more. Our global PKPD group deploys a powerful suite of model-based approaches—including PBPK, PK/PD, QSP, and pharmacometrics—to shape decisions across this diverse portfolio from early discovery through clinical submission and beyond. We are passionate about transforming the lives of patients, developing our people to their full potential, and continuously pushing the boundaries of science. If you are ready to make a tangible difference through quantitative modeling, we invite you to join Team Lilly in Boston or the headquarter in Indianapolis and help shape the future of QSP at Lilly. Position Overview: Join us in tackling some of the most complex and meaningful challenges in medicine. We are seeking a highly motivated, scientifically curious, and collaborative Quantitative Systems Pharmacology (QSP) scientist to work on life-changing therapies for patients. As a hands-on QSP scientist, you will work alongside experienced mentors and cross-functional teams to develop and apply AI-powered QSP models that integrate deep biological knowledge, pharmacology, and preclinical and clinical data to drive pivotal decisions in drug discovery and development. Primary Responsibilities: Design, develop, and implement QSP models to support target evaluation, candidate molecule selection, translational research, and clinical development Synthesize literature, incorporate insights from cross-functional teams, and integrate preclinical, translational, and clinical datasets to build mechanistic models of disease biology and drug action Perform parameter estimation, model simulations and model analysis to inform drug discovery and/or development programs in a timely manner. Clearly communicate modeling results to both technical and non-technical project teams to guide decision making. Provide scientific insights to project teams to support the selection of the right target, molecule, dose, patient population, and development strategies. Champion the application of QSP modeling across Lilly by sharing impactful results and building internal visibility for the discipline Maintain documentation of model development Represent the group and increase external visibility through scientific presentations at external conferences and meetings Author peer-reviewed manuscripts Basic Qualifications: PhD in quantitative pharmacology, systems biology, bioengineering, applied mathematics or related discipline Experience with developing ODE-based models for biological system Experience with R, Matlab/Simbiology, Python, NONMEM, Monolix or other related software for model development Experience with parameter estimation, sensitivity analysis Additional Skills/Preferences: 3 years of experience in developing QSP/mechanistic PKPD models 2 years of experience working in pharmaceutical/biotech industry Experience with development of virtual patient populations Strong understanding of PK/PD, pharmacology, drug discovery and development Experience working with complex biological and clinical datasets Enthusiasm for integrating AI/ML tools and emerging technologies into modeling workflows Familiarity with metabolic disease biology is a strong plus Strong problem solving skills both independently and collaboratively Excellent time-management and organizational skills; thrives in a dynamic, fast-paced environment Ability to clearly communicate scientific concepts and modeling results to multidisciplinary audiences Strong publication record Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources (Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response. Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $166,500 - $244,200 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. WeAreLilly

Keywords: Eli Lilly and Company, Lynn , QSP Modeler, Science, Research & Development , Boston, Massachusetts